pentobarbital will decrease the level or result of lumacaftor/ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.pentobarbital will reduce the extent or effect of artemether/lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration with powerful CYP3A4 induc
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